The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach.

Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes w... Mehr ...

Verfasser: Enrico Giampieri
Edith J. M. Feskens
Claudia Sala
Albert A. de Graaf
Gastone Castellani
Ben van Ommen
Dulce Calçada
Bas Kremer
Jildau Bouwman
Aurelia Santoro
Dario Vianello
Claudio Franceschi
Dokumenttyp: Artikel
Erscheinungsdatum: 2014
Schlagwörter: Netherlands / SDSN - Greece / sdsn-gr / SP1-Cooperation / New dietary strategies addressing the specific needs of elderly population for an healthy ageing in Europe / EC / FP7 / European Commission / Knowmad Institut / projects / Food / Agriculture and Fisheries / and Biotechnology / Developmental Biology / Aging
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29181452
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://www.openaccessrepository.it/record/86421

Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes whose behavior must be understood at multiple levels of biological organization (molecular, cellular, organ, and system levels) and on multiple time scales. Mathematical modeling of such behavior, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems. © 2014 The Authors.