Carbohydrate-based adjuvants.

Carbohydrate adjuvants are safe and biocompatible compounds usable as sustained delivery systems and stimulants of ongoing humoral and cellular immune responses, being especially suitable for the development of vaccines against intracellular pathogens where alum is useless. The development of new adjuvants is difficult and expensive, however, in the last two years, seven new carbohydrate-based adjuvants have been patented, also there are twelve ongoing clinical trials of vaccines that contain carbohydrate-based adjuvants, as well as numerous publications on their mechanism of action and safety... Mehr ...

Verfasser: Garcia-Vello, Pilar
Speciale, Immacolata
Chiodo, Fabrizio
Molinaro, Antonio
De Castro, Cristina
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Schlagwörter: H2020 / Netherlands / Aurora Universities Network / European Training Networks / EC / European Commission / Knowmad Institut / Drug Discovery / Molecular Medicine
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29181411
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://www.openaccessrepository.it/record/83855

Carbohydrate adjuvants are safe and biocompatible compounds usable as sustained delivery systems and stimulants of ongoing humoral and cellular immune responses, being especially suitable for the development of vaccines against intracellular pathogens where alum is useless. The development of new adjuvants is difficult and expensive, however, in the last two years, seven new carbohydrate-based adjuvants have been patented, also there are twelve ongoing clinical trials of vaccines that contain carbohydrate-based adjuvants, as well as numerous publications on their mechanism of action and safety. More research is necessary to improve the existent adjuvants and develop innovative ones.