ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.

Abstract Motivation The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. Results We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations. Availability and Implemen... Mehr ...

Verfasser: Martin Demko
Myriam Boudjoghra
Patricia J. T. A. Groenen
Christiane Pott
Anton W. Langerak
Andrea Grioni
Leopold Sellner
Peter Dreger
Barbora Hanakova
Frederic Davi
Monika Brüggemann
Vojtech Bystry
Henrik Knecht
Marine Pingeon
Max Schlitt
Dietrich Herrmann
Adam Krejci
Tomáš Reigl
Nikos Darzentas
Jos Rijntjes
Dokumenttyp: Artikel
Erscheinungsdatum: 2016
Schlagwörter: Netherlands / Computational Mathematics / Computational Theory and Mathematics / Computer Science Applications / Molecular Biology / Biochemistry / Statistics and Probability
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29181111
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://www.openaccessrepository.it/record/100827

Abstract Motivation The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. Results We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations. Availability and Implementation ARResT/Interrogate is implemented primarily in R, and is freely available at http://bat.infspire.org/arrest/interrogate/ Supplementary information Supplementary data are available at Bioinformatics online.