Multiproblem households that receive social care for multiple problems, such as debts, psychiatric disorders, and domestic violence, may also be disadvantaged in terms of health and social networks. This study examines whether low-income multiproblem households and the general population differ in self-perceived health, mental health, health behaviors, and social networks. We performed a cross-sectional survey among respondents from low-income multiproblem households (n = 105) and the general population (n = 99) in the municipality of Apeldoorn in the Netherlands. Comparisons with national statistics data indicated that our sample of multiproblem households is more disadvantaged in terms of self-perceived health and mental health than low socioeconomic groups in general in the Netherlands. A multiple logistic regression analysis showed that being part of the multiproblem household group versus the general population group was associated with a lower educational level, a lower likelihood of being in paid employment, a lower score with respect to mental health, less alcohol consumption, and less fruit consumption. There were also differences between the groups on other variables, but these were not significant in adjusted analyses. In conclusion, multiproblem households in Apeldoorn had lower scores on mental health, drank fewer alcoholic drinks per week, and ate less fruit than the general population.