Independent and additive association of prenatal famine exposure and intermediary life conditions with adult mortality between age 18-63 years

Objectives To quantify the relation between prenatal famine exposure and adult mortality, taking into account mediating effects of intermediary life conditions. Design Historical follow-up study. Setting The Dutch famine (Hunger Winter) of 1944–1945 which occurred towards the end of WWII in occupied Netherlands. Study population From 408,015 Dutch male births born 1944–1947, examined for military service at age 18, we selected for follow-up all men born at the time of the famine in six affected cities in the Western Netherlands (n = 25,283), and a sample of unexposed time (n = 10,667) and plac... Mehr ...