Cancer in adolescents and young adults in north Netherlands (1989-2003): increased incidence, stable survival and high incidence of second primary tumours

Background: Lack of survival improvement in adolescents and young adults (AYA) with cancer has led to increased awareness of this young population. Design: We carried out a population-based study of incidence and survival of primary tumours and second primary tumours in patients aged 12–24 in north Netherlands. Age-specific incidence rates per 100 000 and 3-year moving means were calculated. Factors associated with incidence and survival were assessed using a Poisson model, log-rank test and multivariate Cox proportional hazards analysis. Results: From 1989 to 2003 a total of 1118 patients wer... Mehr ...

Verfasser: van Gaal, J. C.
Bastiaannet, E.
Schaapveld, M.
Otter, R.
Kluin-Nelemans, J. C.
de Bont, E. S. J. M.
van der Graaf, W. T. A.
Dokumenttyp: TEXT
Erscheinungsdatum: 2009
Verlag/Hrsg.: Oxford University Press
Schlagwörter: epidemiology
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29175133
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://annonc.oxfordjournals.org/cgi/content/short/20/2/365

Background: Lack of survival improvement in adolescents and young adults (AYA) with cancer has led to increased awareness of this young population. Design: We carried out a population-based study of incidence and survival of primary tumours and second primary tumours in patients aged 12–24 in north Netherlands. Age-specific incidence rates per 100 000 and 3-year moving means were calculated. Factors associated with incidence and survival were assessed using a Poisson model, log-rank test and multivariate Cox proportional hazards analysis. Results: From 1989 to 2003 a total of 1118 patients were diagnosed. The total age-specific incidence rates per 100 000 were as follows: males: 13.4 (12–15 years), 26.9 (16–19 years) and 27.5 (20–24 years) and females: 13.9, 20.7 and 20.7. Male : female ratio was 1.32. The overall estimated annual percentage change (EAPC) in incidence was 2.15% ( P < 0.01). Five-year survival was 80.8% and did not improve during the study period. With median follow-up of 5.5 years (range 0.0–16.0) in our cohort the standardized incidence ratio (SIR) of second primary tumours was 30.55 (95% confidence interval = 19.96–44.76, P < 0.05). Conclusions: The total incidence of cancer in AYA increased (EAPC = 2.15%). Survival was unchanged. The SIR of a second primary tumour in this young cohort increased 31-fold. Further research is needed to study this increasing incidence and optimise treatment outcome in these young patients.