Reduction of Coxiella burnetii Prevalence by Vaccination of Goats and Sheep, the Netherlands

Recently, the number of human Q fever cases in the Netherlands increased dramatically. In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii. All pregnant dairy goats and dairy sheep in herds positive for Q fever were culled. We identified the effect of vaccination on bacterial shedding by small ruminants. On the day of culling, samples of uterine fluid, vaginal mucus, and milk were obtained from 957 pregnant animals in 13 herds. Prevalence and bacterial load were reduced in vaccinated animals compared with unvaccinated animals. These effects were... Mehr ...

Verfasser: Lenny Hogerwerf
René van den Brom
Hendrik I.J. Roest
Annemarie Bouma
Piet Vellema
Maarten Pieterse
Daan Dercksen
Mirjam Nielen
Dokumenttyp: Artikel
Erscheinungsdatum: 2011
Reihe/Periodikum: Emerging Infectious Diseases, Vol 17, Iss 3, Pp 379-386 (2011)
Verlag/Hrsg.: Centers for Disease Control and Prevention
Schlagwörter: Q fever / Coxiella burnetii / bacterial vaccine / bacteria / bacterial shedding / goats / Medicine / R / Infectious and parasitic diseases / RC109-216
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29173011
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://doi.org/10.3201/eid1703.101157

Recently, the number of human Q fever cases in the Netherlands increased dramatically. In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii. All pregnant dairy goats and dairy sheep in herds positive for Q fever were culled. We identified the effect of vaccination on bacterial shedding by small ruminants. On the day of culling, samples of uterine fluid, vaginal mucus, and milk were obtained from 957 pregnant animals in 13 herds. Prevalence and bacterial load were reduced in vaccinated animals compared with unvaccinated animals. These effects were most pronounced in animals during their first pregnancy. Results indicate that vaccination may reduce bacterial load in the environment and human exposure to C. burnetii.