Linked nosocomial COVID-19 outbreak in three facilities for people with intellectual and developmental disabilities due to SARS-CoV-2 variant B.1.1.519 with spike mutation T478K in the Netherlands ...

Abstract Background Individuals with intellectual and developmental disabilities (IDD) living in congregated settings have increased risk of COVID-19 infection and mortality. Little is known about variant B.1.1.519 with spike mutation T478K, dominant in Mexico. We describe a linked SARS-CoV-2 B.1.1.519 outbreak in three IDD facilities in the Netherlands. Methods Following notification of the index, subsequent cases were identified through serial PCR group testing. Positive specimens were submitted for whole-genome-sequencing. Clinical information was gathered through interviews with staff memb... Mehr ...

Verfasser: Gorgels, Koen M. F.
Dingemans, Jozef
van der Veer, Brian M. J. W.
Hackert, Volker
Hensels, Audrey Y. J.
den Heijer, Casper D. J.
van Alphen, Lieke B.
Savelkoul, Paul H. M.
Hoebe, Christian J. P. A.
Dokumenttyp: Datenquelle
Erscheinungsdatum: 2022
Verlag/Hrsg.: figshare
Schlagwörter: Medicine / Genetics / FOS: Biological sciences / Biotechnology / 19999 Mathematical Sciences not elsewhere classified / FOS: Mathematics / Cancer / 110309 Infectious Diseases / FOS: Health sciences / 60506 Virology / Computational Biology
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-29167547
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dx.doi.org/10.6084/m9.figshare.c.5834905

Abstract Background Individuals with intellectual and developmental disabilities (IDD) living in congregated settings have increased risk of COVID-19 infection and mortality. Little is known about variant B.1.1.519 with spike mutation T478K, dominant in Mexico. We describe a linked SARS-CoV-2 B.1.1.519 outbreak in three IDD facilities in the Netherlands. Methods Following notification of the index, subsequent cases were identified through serial PCR group testing. Positive specimens were submitted for whole-genome-sequencing. Clinical information was gathered through interviews with staff members of the three facilities. Results Attack rate (AR) in clients of the index facility was 92% (23/25), total AR in clients 45% (33/73) and in staff members 24% (8/34). 55% (18/33) of client cases were asymptomatic, versus 25% (2/8) of staff members. Five client cases (15%) were hospitalized, two died (6%). Sequencing yielded the same specific B.1.1.519 genotype in all three facilities. No significant difference in ...