A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study. ...
Funder: Centre International de Recherche sur le Cancer; doi: http://dx.doi.org/10.13039/100008700 ... : PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index,... Mehr ...
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Dokumenttyp: | Scholarlyarticle |
Erscheinungsdatum: | 2020 |
Verlag/Hrsg.: |
Springer Science and Business Media LLC
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Schlagwörter: | Cohort study / Diet / Epidemiology / Nutrition / Prostate cancer / Cohort Studies / Europe / Genome-Wide Association Study / Humans / Male / Netherlands / Nutrients / Prospective Studies / Prostatic Neoplasms / Risk Factors |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-29160461 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dx.doi.org/10.17863/cam.59699 |
Funder: Centre International de Recherche sur le Cancer; doi: http://dx.doi.org/10.13039/100008700 ... : PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). RESULTS: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, ...