Dementia risk in the general population: large-scale external validation of prediction models in the AGES-Reykjavik study
We aimed to evaluate the external performance of prediction models for all-cause dementia or AD in the general population, which can aid selection of high-risk individuals for clinical trials and prevention. We identified 17 out of 36 eligible published prognostic models for external validation in the population-based AGES-Reykjavik Study. Predictive performance was assessed with c statistics and calibration plots. All five models with a c statistic > .75 (.76-.81) contained cognitive testing as a predictor, while all models with lower c statistics (.67-.75) did not. Calibration ranged from... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Reihe/Periodikum: | European Journal of Epidemiology, vol 36, iss 10 |
Verlag/Hrsg.: |
eScholarship
University of California |
Schlagwörter: | Health Services and Systems / Health Sciences / Dementia / Brain Disorders / Aging / Alzheimer's Disease / Prevention / Acquired Cognitive Impairment / Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) / Neurodegenerative / Neurological / Female / Humans / Male / Netherlands / Population Surveillance / Predictive Value of Tests / Reproducibility of Results / Risk Assessment / Risk Factors / Prognosis / Validation / Alzheimer’s disease / Public Health and Health Services / Epidemiology |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-29158505 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://escholarship.org/uc/item/5ks4w41q |