Efficacy of serology driven "test and treat strategy" for eradication of in patients with rheumatic disease in the Netherlands

International audience ; The treatment of choice of infections is a 7-day triple-therapy with a proton pump inhibitor (PPI) plus amoxicillin and either clarithromycin or metronidazole, depending on local antibiotic resistance rates. The data on efficacy of eradication therapy in a group of rheumatology patients on long-term NSAID therapy are reported here. This study was part of a nationwide, multicenter RCT that took place in 2000-2002 in the Netherlands. Patients who tested positive for IgG antibodies were included and randomly assigned to either eradication PPI-triple therapy or placebo. Af... Mehr ...