Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: Analysis of the HIV-2 Belgium and Luxembourg database

Background: Guidelines established for the treatment of HIV-1 infection and genotype interpretation do not apply for HIV-2. Data about antiretroviral ( ARV) drug efficacy and resistance mutations is scarce. Methods: Clinical data about HIV-2 infected patients in Belgium and Luxembourg were collected and the effect of ARV therapy on plasma viral load and CD4 counts were analysed. Viral RNA encoding for protease ( PR) and reverse transcriptase ( RT) from ARV-naive and treated patients were sequenced. Results: Sixty-five HIV-2 infected patients were included in this cohort. Twenty patients were t... Mehr ...