IntroductionHealthcare systems worldwide are challenged by aging populations, non-communicable diseases and polypharmacy. All three factors may contribute to the risk for drug-related problems (DRP). DRP are responsible for 5–17% of acute hospitalizations and by interfering with desired health outcomes, they pose both health and economic problems. A paradigm shift in healthcare policy is needed. Belgium started 12 local pilot projects to better streamline care for people with a chronic condition and to test different strategies for implementing integrated care. The Chronilux project (Luxembourg, Belgium) is aiming to assess the feasibility and impact of medication review (MR) in the care pathway of a chronically ill patient by a more integrated approach. Brief description of the change in practice implementedA structured pathway, involving the family pharmacist and the home care nurse, with the patient and the caregiver at the centre of this pathway, will enable a more comprehensive approach to care thanks to sharing of professional skills leading to a clear increase in the quality of care. The general practitioner remains the key person in charge of the medical record, but multidisciplinary collaboration enables a safer and more effective pharmacotherapy. Healthcare providers find their rightful place within a clearly defined framework. Objective and theory of changeTo assess the feasibility and impact of MR in the care pathway of a chronically ill patient through an integrated polymedication management. Target population and stakeholdersOutpatients taking at least 5 chronic medications and living in the province of Luxembourg. All relevant professional organizations are involved in the project. Chronilux is financially supported by the federal government. TimelineCo-creation process (2020) and pilot (2021) Highlights (innovation, impact and outcomes)The integration of care is facilitated by a streamlined organization of work and a common vision of care. The co-creation process has already led to quality ...