This report examines the politics of differentiated integration (DI) in Luxembourg between 2004 and 2020. It looks at the salience of DI in government discourse at the conceptual level and also in terms of more concrete references to DI mechanisms and instances. The report aims to define the position of the government of Luxembourg – understood broadly as the set of all political actors. The report relies on quantitative text analysis and qualitative analysis of the salience of DI and Luxembourg’s position on it. Overall, references to DI concepts are rare, although the idea of a multi-speed Europe has been debated. References to DI mechanisms (enhanced cooperation and opt-outs) and specific instances are more frequent than conceptual references in parliamentary debates. The government of Luxembourg generally adopts a neutral or positive position on DI (concepts, mechanisms and instances). Luxembourg supports DI when it refers to a multi-speed Europe in which the country can act as an example of European integration and incentivise other Member States to follow its path. In accordance, Luxembourg tends to reject opt-out mechanisms for Member States in EU law while supporting (and joining) most instances of enhanced cooperation. In general, Luxembourg participates in most mechanisms that can put the country at the vanguard of European integration. In stark contrast, Luxembourg opposed one important instance of enhanced cooperation which it considered would hurt its core financial interests (the Financial Transaction Tax). ; This paper is part of the InDivEU project which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 822304. The content of this document represents only the views of the InDivEU consortium and is its sole responsibility. The European Commission does not accept any responsibility for use that may be made of the information it contains.