This study was conducted to investigate the influence of Holland’s personality-environment congruence on academic performance, overall satisfaction, and self-esteem among bachelor degree students at Assumption University. Two hundred and ninety six junior and senior students completed a self-administered questionnaire which measured the study’s primary variables (degree of congruence, academic performance, overall satisfaction, and self-esteem). The findings indicated that the respondents reported no significant level of congruence influence on academic performance. However, the results showed a significant positive correlation on overall satisfaction and minor significant negative correlation on self-esteem. These findings demonstrate that even though personality-environment congruence does not have any significant effect on academic performance or has only minor negative significant effect on self-esteem, many other scientific researchers also support the idea that personality-environment congruence influences overall satisfaction and this overall satisfaction affects academic performance and then academic performance affects self-esteem. It is suggested that future research should investigate these pattern of relationships in both Thai educational settings as well as work settings. There is still much room for further research in this area within the Thai context.