Information and Communication Technology (ICT) became a measure of the level of progress of an organization and shows its ability to compete. There is no doubt that the applications of Artificial Intelligence (AI) have contributed to a technological progress in various fields among which is expert systems, which is defined simply as the system that replaces or assists a human expert in a complex task that requires specialized knowledge. The fundamental purpose of the present study is to propose and develop an expert system to guide high school students in choosing the appropriate university major at Hebron University as a case study. In addition, the system uses both rules and machine learning algorithms to analyze the student's characteristics and abilities and to display the best university programs that suit his personality. The results showed that 85% of the students were satisfied with using the system and recommended using it.