Immunophenotype of the inflammatory response in the central and enteric nervous systems of cockatiels ( Nymphicus hollandicus ) experimentally infected with parrot bornavirus 2 ...

Proventricular dilatation disease is a lethal disease of psittacine birds. In this study, we characterized the local cellular immune response in the brain, proventriculus, and small intestine of 27 cockatiels ( Nymphicus hollandicus ) experimentally infected with parrot bornavirus 2 (PaBV-2). Perivascular cuffs in the brain were composed of CD3+ T-lymphocytes and Iba1+ macrophages/microglia in most cockatiels (n = 26). In the ganglia of the proventriculus, CD3+ T-lymphocytes (n = 17) and Iba1+ macrophages (n = 13) prevailed. The ganglia of the small intestine had a more homogeneous distributio... Mehr ...

Verfasser: Leal de Araújo, Jeann
Rech, Raquel R.
Rodrigues-Hoffmann, Aline
Giaretta, Paula R.
Cirqueira, Cinthya
Wenceslau, Raphael Rocha
Tizard, Ian
Diaz-Delgado, Josué
Dokumenttyp: Datenquelle
Erscheinungsdatum: 2022
Verlag/Hrsg.: SAGE Journals
Schlagwörter: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified / FOS: Clinical medicine / 70706 Veterinary Medicine / FOS: Veterinary sciences
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-29070430
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dx.doi.org/10.25384/sage.c.5784300.v1

Proventricular dilatation disease is a lethal disease of psittacine birds. In this study, we characterized the local cellular immune response in the brain, proventriculus, and small intestine of 27 cockatiels ( Nymphicus hollandicus ) experimentally infected with parrot bornavirus 2 (PaBV-2). Perivascular cuffs in the brain were composed of CD3+ T-lymphocytes and Iba1+ macrophages/microglia in most cockatiels (n = 26). In the ganglia of the proventriculus, CD3+ T-lymphocytes (n = 17) and Iba1+ macrophages (n = 13) prevailed. The ganglia of the small intestine had a more homogeneous distribution of these leukocytes, including PAX5+ B-lymphocytes (n = 9), CD3+ T-lymphocytes (n = 8), and Iba1+ macrophages (n = 8). Our results indicate that perivascular cuffs in the brain and the inflammatory infiltrate in the proventriculus of PaBV-2-infected cockatiels is predominately composed of T-lymphocytes, while the inflammatory infiltrates in the ganglia of the small intestine are characterized by a mixed infiltrate ...