The data sets include U-series and Neodymium isotope measurements in modern (n = 6) and fossil (n = 24) deep-coral (Desmophyllum dianthus) assemblages raised from the Orphan Knoll and Flemish cap area, southeastern Labrador Sea, during the CCGS Hudson-2010-029 cruise using the tethered Canadian ROPOS ROV, complemented with a single colony from a rock dredge recovery during the CSS Hudson 78-020 expedition. Fossil specimens age clusters are : the mid to late Holocene, the Bølling-Allerød (the single colony), MIS 5c, MIS 7a. Details about the U-series measurements can be found in Maccali et al. (2020). Nd-isotope measurements were reported during the 2015 Goldschmidt Conference by Ménabréaz et al. ( 2015). Low eNd-values point to intervals with a strong imprint of detrital particulate fluxes from the Greenland and Canadian Precambrian basements on the intermediate water mass of the Labrador Sea (~ 1600-2200 m). The more radiogenic end-member (eNd ~ -13.5) corresponds to the modern-like signature of the North-Atlantic Deep Sea Water.