A novel succinate dehydrogenase subunit B germline variant associated with head and neck paraganglioma in a Dutch kindred: A family‐based study

Objective In the Netherlands, the majority of hereditary head and neck paragangliomas ( HNPGL ) are caused by germline variants in the succinate dehydrogenase genes ( SDHD , SDHB , SDHAF 2). Here, we evaluate a four‐generation family linked to a novel SDHB gene variant with the manifestation of a HNPGL . Design A family‐based study. Setting The VU University Medical Center ( VU mc) Amsterdam, a tertiary clinic for Otolaryngology and Head and Neck Surgery. Participants and main outcome measures The index patients presented with an embryonic rhabdomyosarcoma and a non‐Hodgkin lymphoma. Array‐bas... Mehr ...