Genetic Variation in the Leptin Receptor Gene, Leptin, and Weight Gain in Young Dutch Adults

Abstract Objective : To investigate the association between leptin levels, polymorphisms in the leptin receptor ( LEPR ) gene, and weight gain. Research Methods and Procedures : From two large prospective cohorts in The Netherlands ( n = 17, 500), we compared the baseline leptin of 259 subjects who had gained an average of 12.6 kg (range 5.5 to 33 kg) with 277 subjects who kept stable weight (range −2.6 to 3.1 kg) after a mean follow‐up of 6.8 years. Three polymorphisms in the LEPR gene (Lys109Arg, Gln223Arg, and Lys656Asn) were determined. Results : Weight gainers had significantly higher bas... Mehr ...