Standardized serum hepcidin values in Dutch children: Set point relative to body iron changes during childhood

Abstract Background Use of serum hepcidin measurements in pediatrics would benefit from standardized age‐ and sex‐specific reference ranges in children, in order to enable the establishment of clinical decision limits that are universally applicable. Procedure We measured serum hepcidin‐25 levels in 266 healthy Dutch children aged 0.3‐17 years, using an isotope dilution mass spectrometry assay, standardized with our commutable secondary reference material (RM), assigned by a candidate primary RM. Results We constructed age‐ and sex‐specific values for serum hepcidin and its ratio with ferritin... Mehr ...