Establishment of the Dutch Nationwide, Interdisciplinary Infrastructure and Biobank for Fundamental and Translational Ovarian Cancer Research:Archipelago of Ovarian Cancer Research (AOCR)

OBJECTIVES: Ovarian cancer has the worst overall survival rate of all gynecologic malignancies. For the majority of patients, the 5-year overall survival rate of less than 50% has hardly improved over the last decades. To improve the outcome of patients with all subtypes of ovarian cancer, large-scale fundamental and translational research is needed. To accommodate these types of ovarian cancer research, we have established a Dutch nationwide, interdisciplinary infrastructure and biobank: the Archipelago of Ovarian Cancer Research (AOCR). The AOCR will facilitate fundamental and translational... Mehr ...

Verfasser: Zelisse, Hein S.
van Gent, Mignon D.J.M.
de Ridder, Sander
van der Aa, Maaike A.
van Altena, Anne M.
Bart, Joost
Belien, Jeroen A.M.
Boere, Ingrid A.
Bosch, Steven L.
Broeks, Annegien
Bulten, Johan
Collée, Margriet
Groenendijk, Floris H.
Horlings, Hugo M.
Jansen, Maurice P.H.M.
Jonges, Trudy G.N.
Kooreman, Loes F.S.
de Kroon, Cornelis D.
Lambrechts, Sandrina
Lok, Christianne A.R.
Piek, Jurgen M.
Reyners, Anna K.L.
Roes, Eva Maria
Simons, Michiel
Wisman, G. Bea A.
Yigit, Refika
Zweemer, Ronald P.
Mom, Constantijne H.
van de Vijver, Marc J.
Dijk, Frederike
Dokumenttyp: Artikel
Erscheinungsdatum: 2023
Reihe/Periodikum: Zelisse , H S , van Gent , M D J M , Archipelago of Ovarian Cancer Research Consortium , de Ridder , S , van der Aa , M A , van Altena , A M , Bart , J , Belien , J A M , Boere , I A , Bosch , S L , Broeks , A , Bulten , J , Collée , M , Groenendijk , F H , Horlings , H M , Jansen , M P H M , Jonges , T G N , Kooreman , L F S , de Kroon , C D , Lambrechts , S , Lok , C A R , Piek , J M , Reyners , A K L , Roes , E M , Simons , M , Wisman , G B A , Yigit , R , Zweemer , R P , Mom , C H , van de Vijver , M J & Dijk , F 2023 , ' Establishment of the Dutch Nationwide, Interdisciplinary Infrastructure and Biobank for Fundamental and Translational Ovarian Cancer Research : Archipelago of Ovarian Cancer Research (AOCR) ' , Gynecologic and Obstetric Investigation , vol. 87 , no. 6 , pp. 389-397 . https://doi.org/10.1159/000528330
Schlagwörter: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29044020
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://pure.eur.nl/en/publications/8ac1b1e2-d67f-4a96-865d-e38edea51e5f

OBJECTIVES: Ovarian cancer has the worst overall survival rate of all gynecologic malignancies. For the majority of patients, the 5-year overall survival rate of less than 50% has hardly improved over the last decades. To improve the outcome of patients with all subtypes of ovarian cancer, large-scale fundamental and translational research is needed. To accommodate these types of ovarian cancer research, we have established a Dutch nationwide, interdisciplinary infrastructure and biobank: the Archipelago of Ovarian Cancer Research (AOCR). The AOCR will facilitate fundamental and translational ovarian cancer research and enhance interdisciplinary, national, and international collaboration. DESIGN: The AOCR biobank is a prospective ovarian cancer biobank in which biomaterials are collected, processed, and stored in a uniform matter for future (genetic) scientific research. All 19 Dutch hospitals in which ovarian cancer surgery is performed participate and collaborate in the AOCR biobank. PARTICIPANTS/MATERIALS, SETTING, METHODS: Patients of 16 years and older with suspected or diagnosed ovarian, fallopian tube, or primary peritoneal cancer are recruited for participation. Patients who agree to participate give written informed consent for collection, storage, and issue of their biomaterials for future studies. After inclusion, different blood samples are taken at various predefined time points both before and during treatment. In case of a diagnostic paracentesis or biopsy, the residual biomaterials of these procedures are stored in the biobank. During surgery, primary tumor tissue and, if applicable, tissue from metastatic sites are collected and stored. From each patient, a representative histological hematoxylin and eosin stained slide is digitalized for research purposes, including reassessment by a panel of gynecologic pathologists. Clinical and pathological data are obtained on a per-study basis from Dutch registries. Research proposals for the issue of biomaterials and data are evaluated by both the ...