Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors:A Case Control Study in the Dutch Childhood Cancer Survivor Study

BACKGROUND: Plasma biomarkers may aid in the detection of anthracycline-related cardiomyopathy (ACMP). However, the cur-rently available biomarkers have limited diagnostic value in long-term childhood cancer survivors. This study sought to identify diagnostic plasma biomarkers for ACMP in childhood cancer survivors. METHODS AND RESULTS: We measured 275 plasma proteins in 28 ACMP cases with left ventricular ejection fraction <45%, 29 anthracycline-treated controls with left ventricular ejection fraction ≥53% matched on sex, time after cancer, and anthracy-cline dose, and 29 patients with gen... Mehr ...

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Verfasser: Leerink, Jan M.
Feijen, Elizabeth A.M.
Moerland, Perry D.
de Baat, Esmee C.
Merkx, Remy
van der Pal, Helena J.H.
Tissing, Wim J.E.
Louwerens, Marloes
van den Heuvel-Eibrink, Marry M.
Versluys, A. Birgitta
Asselbergs, Folkert W.
Sammani, Arjan
Teske, Arco J.
van Dalen, Elvira C.
van der Heiden-Van der Loo, Margriet
van Dulmen-Den Broeder, Eline
de Vries, Andrica C.H.
Kapusta, Livia
Loonen, Jacqueline
Pinto, Yigal M.
Kremer, Leontien C.M.
Mavinkurve-Groothuis, Annelies M.C.
Kok, Wouter E.M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Leerink , J M , Feijen , E A M , Moerland , P D , de Baat , E C , Merkx , R , van der Pal , H J H , Tissing , W J E , Louwerens , M , van den Heuvel-Eibrink , M M , Versluys , A B , Asselbergs , F W , Sammani , A , Teske , A J , van Dalen , E C , van der Heiden-Van der Loo , M , van Dulmen-Den Broeder , E , de Vries , A C H , Kapusta , L , Loonen , J , Pinto , Y M , Kremer , L C M , Mavinkurve-Groothuis , A M C & Kok , W E M 2022 , ' Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors : A Case Control Study in the Dutch Childhood Cancer Survivor Study ' , Journal of the American Heart Association , vol. 11 , no. 14 , e025935 . https://doi.org/10.1161/JAHA.121.025935
Schlagwörter: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29043705
Datenquelle: BASE; Originalkatalog
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Link(s) : https://pure.eur.nl/en/publications/3d48479d-138f-4e01-8ea3-b606f5651b7d