The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

The importance of the one-carbon metabolites, choline and homocysteine, to brain function is well known. However, the associations between the one-carbon metabolites choline, betaine, methionine and dimethylglycine with cognition in elderly are unclear. We therefore examined the associations of these metabolites with cognition in a double-blind, placebo-controlled trial. Individuals ( n 195) were randomized to receive daily oral capsules with either 1000 μg cobalamin (vitamin B 12 ), or 1000 μg cobalamin plus 400 μg folic acid, or placebo for 24 weeks. Concentrations of homocysteine, methionin... Mehr ...