Resequencing Three Candidate Genes for Major Depressive Disorder in a Dutch Cohort

Major depressive disorder (MDD) is a psychiatric disorder, characterized by periods of low mood of more than two weeks, loss of interest in normally enjoyable activities and behavioral changes. MDD is a complex disorder and does not have a single genetic cause. In 2009 a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. Many of the top signals of this GWAS mapped to a region spanning the gene PCLO, and the non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became genome wide significant after post-hoc analysis. We performed rese... Mehr ...

Verfasser: Verbeek, EC
Bevova, MR
Bochdanovits, Z
Rizzu, P
Bakker, IMC
Uithuisje, T
de Geus, EJ
Smit, JH
Penninx, BW
Boomsma, DI
Hoogendijk, Witte
Heutink, P
Dokumenttyp: Artikel
Erscheinungsdatum: 2013
Reihe/Periodikum: Verbeek , EC , Bevova , MR , Bochdanovits , Z , Rizzu , P , Bakker , IMC , Uithuisje , T , de Geus , EJ , Smit , JH , Penninx , BW , Boomsma , DI , Hoogendijk , W & Heutink , P 2013 , ' Resequencing Three Candidate Genes for Major Depressive Disorder in a Dutch Cohort ' , PLoS One (print) , vol. 8 , no. 11 , e79921 . https://doi.org/10.1371/journal.pone.0079921
Schlagwörter: /dk/atira/pure/keywords/researchprograms/AFL001000/EMCONWAR015802 / name=EMC ONWAR-01-58-02
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-29042797
Datenquelle: BASE; Originalkatalog
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Link(s) : https://pure.eur.nl/en/publications/9a3e09df-d475-463c-a4dc-98c6ae257c09