The prognostic and predictive value of Tregs and tumor immune subtypes in postmenopausal, hormone receptor-positive breast cancer patients treated with adjuvant endocrine therapy: a Dutch TEAM study analysis

Evidence exists for an immunomodulatory effect of endocrine therapy in hormone receptor-positive (HR+ve) breast cancer (BC). Therefore, the aim of this study was to define the prognostic and predictive value of tumor immune markers and the tumor immune profile in HR+ve BC, treated with different endocrine treatment regimens. 2,596 Dutch TEAM patients were treated with 5 years of adjuvant hormonal treatment, randomly assigned to different regimens: 5 years of exemestane or sequential treatment (2.5 years of tamoxifen-2.5 years of exemestane). Immunohistochemistry was performed for HLA class I,... Mehr ...

Verfasser: Engels, CC
Charehbili, A
van de Velde, CJH
Bastiaannet, E
Sajet, A
Putter, H
van Vliet, EA
van Vlierberghe, RLP
Smit, VTHBM
Bartlett, JMS
Seynaeve, Caroline
Liefers, GJ
Kuppen, PJK
Dokumenttyp: Artikel
Erscheinungsdatum: 2015
Reihe/Periodikum: Engels , CC , Charehbili , A , van de Velde , CJH , Bastiaannet , E , Sajet , A , Putter , H , van Vliet , EA , van Vlierberghe , RLP , Smit , VTHBM , Bartlett , JMS , Seynaeve , C , Liefers , GJ & Kuppen , PJK 2015 , ' The prognostic and predictive value of Tregs and tumor immune subtypes in postmenopausal, hormone receptor-positive breast cancer patients treated with adjuvant endocrine therapy: a Dutch TEAM study analysis ' , Breast Cancer Research and Treatment , vol. 149 , no. 3 , pp. 587-596 . https://doi.org/10.1007/s10549-015-3269-7
Schlagwörter: /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM038601 / name=EMC MM-03-86-01 / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-29042674
Datenquelle: BASE; Originalkatalog
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Link(s) : https://pure.eur.nl/en/publications/79060abb-441e-44aa-8cfb-3e76689389a9

Evidence exists for an immunomodulatory effect of endocrine therapy in hormone receptor-positive (HR+ve) breast cancer (BC). Therefore, the aim of this study was to define the prognostic and predictive value of tumor immune markers and the tumor immune profile in HR+ve BC, treated with different endocrine treatment regimens. 2,596 Dutch TEAM patients were treated with 5 years of adjuvant hormonal treatment, randomly assigned to different regimens: 5 years of exemestane or sequential treatment (2.5 years of tamoxifen-2.5 years of exemestane). Immunohistochemistry was performed for HLA class I, HLA-E, HLA-G, and FoxP3. Tumor immune subtypes (IS) (low, intermediate & high immune susceptible) were determined by the effect size of mono-immune markers on relapse rate. Patients on sequential treatment with high level of tumor-infiltrating FoxP3+ cells had significant (p = 0.019, HR 0.729, 95 % CI 0.560-0.949) better OS. Significant interaction for endocrine treatment and FoxP3+ presence was seen (OS p < 0.001). Tumor IS were only of prognostic value for the sequentially endocrine-treated patients (RFP: p = 0.035, HR intermediate IS 1.420, 95 % CI 0.878-2.297; HR low IS 1.657, 95 % CI 1.131-2.428; BCSS: p = 0.002, HR intermediate IS 2.486, 95 % CI 1.375-4.495; HR low IS 2.422, 95 % CI 1.439-4.076; and OS: p = 0.005, HR intermediate IS 1.509, 95 % CI 0.950-2.395; HR low IS 1.848, 95 % CI 1.277-2.675). Tregs and the tumor IS presented in this study harbor prognostic value for sequentially endocrine-treated HR+ve postmenopausal BC patients, but not for solely exemestane-treated patients. Therefore, these markers could be used as a clinical risk stratification tool to guide adjuvant treatment in this BC population.