External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort

Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only... Mehr ...

Volltext
Verfasser: Lamain-de Ruiter, Marije
Kwee, Anneke
Naaktgeboren, Christiana A
Louhanepessy, Rebecca D
De Groot, Inge
Evers, Inge M
Groenendaal, Floris
Hering, Yolanda R
Huisjes, Anjoke J M
Kirpestein, Cornel
Monincx, Wilma M
Schielen, Peter C J I
Van 't Zelfde, Annewil
Van Oirschot, Charlotte M
Vankan-Buitelaar, Simone A
Vonk, Mariska A A W
Wiegers, Therese A
Zwart, Joost J
Moons, Karel G M
Franx, Arie
Koster, Maria P H
Dokumenttyp: Artikel
Erscheinungsdatum: 2019
Schlagwörter: First trimester / external validation / preeclampsia / prognostic model / Models / Theoretical / Prognosis / Prospective Studies / Risk Assessment / Humans / Pre-Eclampsia/diagnosis / Pregnancy / Adult / Female / Obstetrics and Gynaecology / Internal Medicine / Journal Article / Multicenter Study / Validation Studies
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29039362
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dspace.library.uu.nl/handle/1874/390530

Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.