CYP3A5 variant allele frequencies in Dutch Caucasians
BACKGROUND: Enzymes of the cytochrome P450 3A (CYP3A) family are responsible for the metabolism of >50% of currently prescribed drugs. CYP3A5 is expressed in a limited number of individuals. The absence of CYP3A5 expression in approximately 70% of Caucasians was recently correlated to a genetic polymorphism (CYP3A5*3). Because CYP3A5 may represent up to 50% of total CYP3A protein in individuals polymorphically expressing CYP3A5, it may have a major role in variation of CYP3A-mediated drug metabolism. Using sequencing, have been identified (Hustert et al. Pharmacogenetics 2001;11:773-9; Kueh... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2002 |
Schlagwörter: | Cytochrome P-450 Enzyme System/blood/*genetics / European Continental Ancestry Group/*genetics / Gene Frequency / Humans / Netherlands / Polymerase Chain Reaction / Polymorphism / Restriction Fragment Length / Variation (Genetics) |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-29035907 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/9981 |