Hereditary frontotemporal dementia is linked to chromosome 17q21-q22: a genetic and clinicopathological study of three Dutch families.

Hereditary frontotemporal dementia (HFTD) is a rare autosomal dominant form of presenile dementia characterized by behavioral changes and reduced speech. Three multigeneration kindreds with this condition, in the Netherlands, were investigated for clinicopathological comparison and linkage analysis. Frontotemporal atrophy on computed tomographic scanning and/or magnetic resonance imaging was usually present. Single-photon emission computed tomography (SPECT) showed frontal hypoperfusion in the early phase of the disease. Brain tissue showed moderate to severe atrophy of frontal and temp

Verfasser: Bakker, E.R.M. (Elvira)
Kros, J.M. (Johan)
Niermeijer, M.F. (Martinus)
Duijn, C.M. (Cornelia) van
Oostra, B.A. (Ben)
Rizzu, P. (Patrizia)
Swieten, J.C. (John) van
Stevens, M. (Martijn)
Heutink, P. (Peter)
Tibben, A. (Arend)
Dokumenttyp: Artikel
Erscheinungsdatum: 1997
Schlagwörter: Chromosomes / Human / Pair 17/*genetics / Dementia/*genetics / Frontal Lobe/*pathology / Frontal lobe dementia / Linkage (Genetics)/*genetics / Middle Aged / Netherlands / Pedigree / Support / Non-U.S. Gov't / Temporal Lobe/*pathology
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29035658
Datenquelle: BASE; Originalkatalog
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Link(s) : http://repub.eur.nl/pub/5772