A Genome-wide linkage study for chronic obstructive pulmonary disease in a dutch genetic isolate identifies novel rare candidate variants

Chronic obstructive pulmonary disease (COPD) is a complex and heritable disease, associated with multiple genetic variants. Specific familial types of COPD may be explained by rare variants, which have not been widely studied. We aimed to discover rare genetic variants underlying COPD through a genome-wide linkage scan. Affected-only analysis was performed using the 6K Illumina Linkage IV Panel in 142 cases clustered in 27 families from a genetic isolate, the Erasmus Rucphen Family (ERF) study. Potential causal variants were identified by searching for shared rare variants in the exome-sequenc... Mehr ...

Verfasser: Prokić, I. (Ivana)
Terzikhan, N. (Natalie)
Vonk, J.M. (Judith)
van der Plaat, D.A. (Diana A.)
Lahousse, L. (Lies)
Diemen, C.C. (Cleo) van
Hobbs, B.D. (Brian D.)
Qiao, D. (Dandi)
Cho, M.H. (Michael)
Brusselle, G.G. (Guy)
Postma, D.S. (Dirkje S.)
Boezen, H.M. (Marike)
Duijn, C.M. (Cornelia) van
Amin, N. (Najaf)
Dokumenttyp: Artikel
Erscheinungsdatum: 2018
Schlagwörter: Chromosome 11 / COPD / Genetic isolate / Genetic linkage analysis / Rare variants
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29035100
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://repub.eur.nl/pub/106152