Identification of a novel idiopathic epilepsy risk locus and a variant in the CCDC85A gene in the Dutch partridge dog

Simple Summary A significant percentage of Dutch partridge dogs suffers from epileptic seizures. Previous studies indicated that this is likely the result of genetic idiopathic epilepsy, but to date, little to no knowledge exists on the genetic cause. This study aimed to identify (a) causal variant(s) and/or risk loci associated with the disease. A risk locus for idiopathic epilepsy was described for the first time on chromosome 12. Furthermore, a variant in the CCDC85A gene was found to increase the risk of disease in homozygous variant dogs. Further research should be conducted to determine... Mehr ...