Iran as a country dominated by oil exports offers unique insights and rich rewards considering its economic and socio-political environment. Although according to a resource-based analysis this economy has the potential of being the world's 20th strongest economy because of its rich reserves in minerals and other natural resources alongside with country's geo-strategic position. It really seems strange and unbelievable how Iran can remain underdeveloped while having so many rare resources highly appreciated by the rest of the world. How we can explain this incoherence? The classic economic model describing Dutch Disease was developed by the economists W. Max Corden and J. Peter Neary in 1982. The so-called "Dutch Disease" as an economic concept explains the seeming relationship between natural resource abundance in a country and decline in other economic sectors specially manufacturing. This theory reveals that an increase in revenues from natural resources will de-industrialize the economy by raising exchange rate, which makes manufacturing sectors to become less competitive. The primary purpose of this paper is to determine if Iranian economy is suffering from this problem and if so what will be the impact of this issue on different sectors economy of Iran. In this paper, using an applied general equilibrium model, and not partial equilibrium model, we analyze Dutch disease in Iranian economy. We use the model that has been made by Dr Lofgren as a base and extend and adjust it for Iran economy. In order to solve the general equilibrium pattern numerically, GAMS software package can be used which is a powerful tool for solving linear and nonlinear equations. ; La notion de syndrome hollandais n’est pas une notion nouvelle mais elle reste toujours d’actualité car l’expansion pétrolière dans un pays en développement produit des effets pervers dans l’économie du pays. Cela se traduit par la contraction des secteurs produisant des biens échangeables en dehors du secteur en boom et le développement des secteurs ...