Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors:A Case Control Study in the Dutch Childhood Cancer Survivor Study

Background Plasma biomarkers may aid in the detection of anthracycline-related cardiomyopathy (ACMP). However, the currently available biomarkers have limited diagnostic value in long-term childhood cancer survivors. This study sought to identify diagnostic plasma biomarkers for ACMP in childhood cancer survivors. Methods and Results We measured 275 plasma proteins in 28 ACMP cases with left ventricular ejection fraction = 53% matched on sex, time after cancer, and anthracycline dose, and 29 patients with genetically determined dilated cardiomyopathy with left ventricular ejection fraction

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Verfasser: Leerink, Jan M.
Feijen, Elizabeth A. M.
Moerland, Perry D.
de Baat, Esmee C.
Merkx, Remy
van der Pal, Helena J. H.
Tissing, Wim J. E.
Louwerens, Marloes
van den Heuvel-Eibrink, Marry M.
Versluys, A. Birgitta
Asselbergs, Folkert W.
Sammani, Arjan
Teske, Arco J.
van Dalen, Elvira C.
van der Heiden-van der Loo, Margriet
van Dulmen-den Broeder, Eline
de Vries, Andrica C. H.
Kapusta, Livia
Loonen, Jacqueline
Pinto, Yigal M.
Kremer, Leontien C. M.
Mavinkurve-Groothuis, Annelies M. C.
Kok, Wouter E. M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Leerink , J M , Feijen , E A M , Moerland , P D , de Baat , E C , Merkx , R , van der Pal , H J H , Tissing , W J E , Louwerens , M , van den Heuvel-Eibrink , M M , Versluys , A B , Asselbergs , F W , Sammani , A , Teske , A J , van Dalen , E C , van der Heiden-van der Loo , M , van Dulmen-den Broeder , E , de Vries , A C H , Kapusta , L , Loonen , J , Pinto , Y M , Kremer , L C M , Mavinkurve-Groothuis , A M C & Kok , W E M 2022 , ' Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors : A Case Control Study in the Dutch Childhood Cancer Survivor Study ' , Journal of the American Heart Association , vol. 11 , no. 14 , 025935 . https://doi.org/10.1161/JAHA.121.025935
Schlagwörter: anthracycline-related cardiomyopathy / biomarkers / cancer therapy-related cardiac dysfunction / cardio-oncology / chemokine ligands / childhood cancer survivors / INCIDENT HEART-FAILURE / CARDIAC DYSFUNCTION / DOXORUBICIN / MARKER
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29029301
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/ff209f6d-f895-4403-8a35-14d31e63e185