Management of infection prophylaxis in Dutch patients with myelodysplastic syndromes, a web-based case vignette questionnaire:the MINDSET study

OBJECTIVES: Infections are a major cause of morbidity and mortality in patients with myelodysplastic syndromes (MDS). The objective of the MINDSET study was to evaluate haematologists' management of infection prevention in MDS patients using a case vignette study and to assess the availability of guidelines. METHODS: We conducted a web-based, nationwide survey amongst haematologists in the Netherlands between September and December 2021. The survey included a set of case vignettes. Additionally, the availability of protocols was evaluated. RESULTS: Sixty responses were obtained (23.6%). These... Mehr ...

Verfasser: Rozema, Johanne
Roon, Eric van
Vogelzang, Lars
Kibbelaar, Robby
Veeger, Nic
van de Loosdrecht, Arjan
Mels, Hoogendoorn
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Rozema , J , Roon , E V , Vogelzang , L , Kibbelaar , R , Veeger , N , van de Loosdrecht , A & Mels , H 2022 , ' Management of infection prophylaxis in Dutch patients with myelodysplastic syndromes, a web-based case vignette questionnaire : the MINDSET study ' , European Journal of Haematology , vol. 109 , no. 4 , pp. 381-387 . https://doi.org/10.1111/ejh.13820
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29029138
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/ec5e65a4-214b-459f-af0a-6fc55f89915b

OBJECTIVES: Infections are a major cause of morbidity and mortality in patients with myelodysplastic syndromes (MDS). The objective of the MINDSET study was to evaluate haematologists' management of infection prevention in MDS patients using a case vignette study and to assess the availability of guidelines. METHODS: We conducted a web-based, nationwide survey amongst haematologists in the Netherlands between September and December 2021. The survey included a set of case vignettes. Additionally, the availability of protocols was evaluated. RESULTS: Sixty responses were obtained (23.6%). These responses were well distributed across hospital types as well as level of experience. No protocols regarding infection prophylaxis specifically for MDS patients were received. In the case vignette of a 75-year-old MDS patient, respondents would primarily prescribe infection prophylaxis in case of recurrent infections (96.7%) and neutropenia (75.0% for absolute neutrophil count [ANC]<0.2x10^9/L and 53.3% for ANC<0.5x10^9/L), especially in combination with hypomethylating agents (80.0%), lenalidomide (66.7%) or chemotherapy (51.7%). Respondents would predominantly choose antibacterial agents (85.0%), followed by antifungal agents (71.7%). CONCLUSIONS: This study showed diverse reasons and considerations of haematologists regarding whether to prescribe infection prophylaxis in MDS patients. Given the seriousness of infections in MDS patients, patient-tailored recommendations might be valuable in clinical decision-making. This article is protected by copyright. All rights reserved.