Frailty and risk of hospitalization from COVID-19 infection among older adults:evidence from the Dutch Lifelines COVID-19 Cohort study

Background Frailty is associated with COVID-19 severity in clinical settings. No general population-based studies on the association between actual frailty status and COVID-19 hospitalization are available. Aims To investigate the association between frailty and the risk of COVID-19 hospitalization once infected. Methods 440 older adults who participated in the Lifelines COVID-19 Cohort study in the Northern Netherlands and reported positive COVID-19 testing results (54.2% women, age 70 +/- 4 years in 2021) were included in the analyses. COVID-19 hospitalization status was self-reported. The G... Mehr ...

Verfasser: Zhu, Yinjie
Sealy, Martine J.
Jager-Wittenaar, Harriet
Mierau, Jochen O.
Bakker, Stephan J. L.
Navis, Gerjan J.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Lifelines Corona Res Initiative , Zhu , Y , Sealy , M J , Jager-Wittenaar , H , Mierau , J O , Bakker , S J L & Navis , G J 2022 , ' Frailty and risk of hospitalization from COVID-19 infection among older adults : evidence from the Dutch Lifelines COVID-19 Cohort study ' , Aging Clinical and Experimental Research , vol. 34 , no. 11 , pp. 2693–2702 . https://doi.org/10.1007/s40520-022-02268-9
Schlagwörter: Frailty / Groningen Frailty Indicator / COVID-19 / Coronavirus / DEFINITION / REGRESSION / INDICATOR / VALIDITY
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29028858
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/c974fdad-9c19-4bb5-9b61-ae0b08d956fd

Background Frailty is associated with COVID-19 severity in clinical settings. No general population-based studies on the association between actual frailty status and COVID-19 hospitalization are available. Aims To investigate the association between frailty and the risk of COVID-19 hospitalization once infected. Methods 440 older adults who participated in the Lifelines COVID-19 Cohort study in the Northern Netherlands and reported positive COVID-19 testing results (54.2% women, age 70 +/- 4 years in 2021) were included in the analyses. COVID-19 hospitalization status was self-reported. The Groningen Frailty Indicator (GFI) was derived from 15 self-reported questionnaire items related to daily activities, health problems, and psychosocial functioning, with a score >= 4 indicating frailty. Both frailty and COVID-19 hospitalization were assessed in the same period. Poisson regression models with robust standard errors were used to analyze the associations between frailty and COVID-19 hospitalization. Results Of 440 older adults included, 42 were hospitalized because of COVID-19 infection. After adjusting for sociodemographic and lifestyle factors, a higher risk of COVID-19 hospitalization was observed for frail individuals (risk ratio (RR) [95% CI] 1.97 [1.06-3.67]) compared to those classified as non-frail. Discussion Frailty was positively associated with COVID-19 hospitalization once infected, independent of sociodemographic and lifestyle factors. Future research on frailty and COVID-19 should consider biomarkers of aging and frailty to understand the pathophysiological mechanisms and manifestations between frailty and COVID-19 outcomes. Conclusions Frailty was positively associated with the risk of hospitalization among older adults that were infected with COVID-19. Public health strategies for frailty prevention in older adults need to be advocated, as it is helpful to reduce the burden of the healthcare system, particularly during a pandemic like COVID-19.