The Dutch Bipolar Offspring Study:12-Year Follow-Up
Objective: Offspring of bipolar parents have a genetically increased risk of developing mood disorders. In a longitudinal study, the authors followed a bipolar offspring cohort from adolescence into adulthood to determine the onset, prevalence, and early course of mood disorders and other psychopathology. Method: The Dutch bipolar offspring cohort is a fixed cohort initiated in 1997 (N=140; age range at baseline, 12-21 years). Bipolar offspring were psychiatrically evaluated at baseline and at 1-, 5-, and 12-year follow-ups. Of the original sample, 77% (N=108) were followed for the full 12 yea... Mehr ...
Verfasser: | |
---|---|
Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2013 |
Reihe/Periodikum: | Mesman , E , Nolen , W A , Reichart , C G , Wals , M & Hillegers , M N J 2013 , ' The Dutch Bipolar Offspring Study : 12-Year Follow-Up ' , American Journal of Psychiatry , vol. 170 , no. 5 , pp. 542-549 . https://doi.org/10.1176/appi.ajp.2012.12030401 |
Schlagwörter: | WELL AMISH CHILDREN / PSYCHIATRIC-DISORDERS / PRODROMAL FEATURES / HIGH-RISK / PARENTS / PSYCHOPATHOLOGY / SCHIZOPHRENIA / METAANALYSIS / RELIABILITY / PREVALENCE |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-29028808 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://hdl.handle.net/11370/c37c1cad-c509-4a99-a7db-896c7180d68c |
Objective: Offspring of bipolar parents have a genetically increased risk of developing mood disorders. In a longitudinal study, the authors followed a bipolar offspring cohort from adolescence into adulthood to determine the onset, prevalence, and early course of mood disorders and other psychopathology. Method: The Dutch bipolar offspring cohort is a fixed cohort initiated in 1997 (N=140; age range at baseline, 12-21 years). Bipolar offspring were psychiatrically evaluated at baseline and at 1-, 5-, and 12-year follow-ups. Of the original sample, 77% (N=108) were followed for the full 12 years. Results: Overall, 72% of the bipolar offspring developed a lifetime DSM-IV axis I disorder, 54% a mood disorder, and 13% bipolar spectrum disorders. Only 3% met DSM-IV criteria for bipolar I disorder. In 88% of the offspring with a bipolar spectrum disorder, the illness started with a depressive episode. In total, 24% of offspring with a unipolar mood disorder developed a bipolar spectrum disorder over time. Mood disorders were often recurrent (31%), were complex (comorbidity rate, 67%), and started before age 25. Conclusions: Even after 12 years of follow-up, from adolescence into adulthood, bipolar I disorder was rare among bipolar offspring. Nevertheless, the risk of developing severe and recurrent mood disorders and other psychopathology was high. Future follow-up of this and other adult bipolar offspring cohorts is essential to determine whether recurrent mood disorders in bipolar offspring reflect the early stages of bipolar disorder. (Am J Psychiatry 2013; 170:542-549)