The effect of childhood adversity on 4-year outcome in individuals at ultra high risk for psychosis in the Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial

Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for developing a psychosis. Structural Equation Modeling was used to examine the effect of childhood adversity on depression, anxiety, transition to psychosis and overall functioning at 4-year follow-up. In addition, we evaluated economic costs of childhood adversity in terms of health... Mehr ...

Verfasser: Kraan, Tamar C
Ising, Helga K
Fokkema, Marjolein
Velthorst, Eva
van den Berg, David P G
Kerkhoven, Margot
Veling, Wim
Smit, Filip
Linszen, Don H.
Nieman, Dorien H
Wunderink, Lex
Boonstra, Nynke
Klaassen, Rianne M C
Dragt, Sara
Rietdijk, Judith
de Haan, Lieuwe
van der Gaag, Mark
Dokumenttyp: Artikel
Erscheinungsdatum: 2017
Reihe/Periodikum: Kraan , T C , Ising , H K , Fokkema , M , Velthorst , E , van den Berg , D P G , Kerkhoven , M , Veling , W , Smit , F , Linszen , D H , Nieman , D H , Wunderink , L , Boonstra , N , Klaassen , R M C , Dragt , S , Rietdijk , J , de Haan , L & van der Gaag , M 2017 , ' The effect of childhood adversity on 4-year outcome in individuals at ultra high risk for psychosis in the Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial ' , Psychiatry Research , vol. 247 , pp. 55-62 . https://doi.org/10.1016/j.psychres.2016.11.014
Schlagwörter: CLINICAL HIGH-RISK / COGNITIVE-BEHAVIORAL THERAPY / POSTTRAUMATIC-STRESS-DISORDER / MAXIMUM-LIKELIHOOD-ESTIMATION / EARLY TRAUMATIC EXPERIENCES / STRUCTURAL EQUATION MODELS / FOLLOW-UP / MISSING DATA / METAANALYSIS / VALIDATION
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29028159
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/7ffe7b99-1495-42fa-b90c-cdd401d6fec0

Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for developing a psychosis. Structural Equation Modeling was used to examine the effect of childhood adversity on depression, anxiety, transition to psychosis and overall functioning at 4-year follow-up. In addition, we evaluated economic costs of childhood adversity in terms of health care use and productivity loss. Data pertain to 105 UHR participants of the Dutch Early Detection and Intervention Evaluation (EDIE-NL). Physical abuse was associated with higher depression rates (b=0.381, p=0.012) and lower social functional outcome (b=-0.219, p=0.017) at 4-year follow-up. In addition, emotional neglect was negatively associated with social functioning (b=-0.313, p=0.018). We did not find evidence that childhood adversity was associated with transition to psychosis, but the experience of childhood adversity was associated with excess health care costs at follow-up. The data indicate long-term negative effects of childhood adversity on depression, social functioning and health care costs at follow-up in a sample of UHR patients.