Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in dutch Caucasians

Context: Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians. Objectives: To investigate the broader significance of this association for DM2, replication studies in distinct ethic populations are required. We investigated ATF6 for its association with DM2 in Dutch Caucasians. Design/Setting: A genetic association study was conducted at an academic research laboratory. Study Participants: Two independent Dutch coh... Mehr ...

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Verfasser: Meex, Steven J. R.
van Greevenbroek, Marleen M. J.
Ayoubi, Torik A.
Vlietinck, Robert
van Vliet-Ostaptchouk, Jana V.
Hofker, Martin H.
Vermeulen, Vicky M. M. -J.
Schalkwijk, Casper G.
Feskens, Edith J. M.
Boer, Jolanda M. A.
Stehouwer, Coen D. A.
van der Kallen, Carla J. H.
de Bruin, Tjerk W. A.
Dokumenttyp: Artikel
Erscheinungsdatum: 2007
Reihe/Periodikum: Meex , S J R , van Greevenbroek , M M J , Ayoubi , T A , Vlietinck , R , van Vliet-Ostaptchouk , J V , Hofker , M H , Vermeulen , V M M -J , Schalkwijk , C G , Feskens , E J M , Boer , J M A , Stehouwer , C D A , van der Kallen , C J H & de Bruin , T W A 2007 , ' Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in dutch Caucasians ' , Journal of Clinical Endocrinology and Metabolism , vol. 92 , no. 7 , pp. 2720-2725 . https://doi.org/10.1210/jc.2006-2280
Schlagwörter: ENDOPLASMIC-RETICULUM STRESS / ER STRESS / MESSENGER-RNA / INTOLERANCE / POPULATION / VARIANTS / MELLITUS / OBESITY / ATF6
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29028088
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/775fc271-12f5-4c1f-8059-2415538fadcd