Discontinuation and dose adjustment of metoprolol after metoprolol-paroxetine/fluoxetine co-prescription in Dutch elderly
PurposeCo-prescription of paroxetine/fluoxetine (a strong CYP2D6 inhibitor) in metoprolol (a CYP2D6 substrate) users is common, but data on the clinical consequences of this drug-drug interaction are limited and inconclusive. Therefore, we assessed the effect of paroxetine/fluoxetine initiation on the existing treatment with metoprolol on the discontinuation and dose adjustment of metoprolol among elderly. MethodsWe performed a cohort study using the University of Groningen IADB.nl prescription database (www.IADB.nl). We selected all elderly (60years) who had ever been prescribed metoprolol an... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2018 |
| Reihe/Periodikum: | Bahar , M A , Wang , Y , Bos , J H J , Wilffert , B & Hak , E 2018 , ' Discontinuation and dose adjustment of metoprolol after metoprolol-paroxetine/fluoxetine co-prescription in Dutch elderly ' , Pharmacoepidemiology and Drug Safety , vol. 27 , no. 6 , pp. 621-629 . https://doi.org/10.1002/pds.4422 |
| Schlagwörter: | citalopram / CYP2D6 / drug-drug interactions (DDI) / metoprolol / mirtazapine / paroxetine / fluoxetine / pharmacoepidemiology / SEROTONIN REUPTAKE INHIBITORS / DRUG-DRUG INTERACTIONS / HUMAN LIVER-MICROSOMES / HEALTHY-VOLUNTEERS / INTRAINDIVIDUAL VARIABILITY / CLINICAL-PHARMACOLOGY / COMMUNITY PHARMACIES / TREATED PATIENTS / CYP2D6 GENOTYPE / IADB |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-29027425 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://hdl.handle.net/11370/302cf3ba-5124-4315-a0b5-13d2b1674033 |
