Background: The prognostic value of WHO grade in pancreatic neuroendocrine tumors (PanNETs) in patients with Multiple Endocrine Neoplasia Type 1 (MEN1) is unknown. Methods: We performed a cohort study using the Dutch National MEN1 database, which includes >90% of the Dutch MEN1 population with data collected between 1990 and 2014. Formalin-fixed paraffin embedded tissue blocks from the largest resected PanNET per patient were collected. MIB1 staining was performed and KI67 labeling index (LI) was determined by manual eye-counting under a microscope and by digital image analysis. Mitotic cou... Mehr ...
| Verfasser: |
Conemans, Elfi B.
Brosens, Lodewijk A. A.
Raicu-Ionita, Gabriela M.
Pieterman, Carolina R. C.
de Herder, Wouter W.
Dekkers, Olaf M.
Hermus, Ad R.
van der Horst-Schrivers, Anouk N.
Bisschop, Peter H.
Havekes, Bas
Drent, Madeleine L.
Timmers, H. Th Marc
Offerhaus, G. Johan
Valk, Gerlof D.
Vriens, Menno R. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Conemans , E B , Brosens , L A A , Raicu-Ionita , G M , Pieterman , C R C , de Herder , W W , Dekkers , O M , Hermus , A R , van der Horst-Schrivers , A N , Bisschop , P H , Havekes , B , Drent , M L , Timmers , H T M , Offerhaus , G J , Valk , G D & Vriens , M R 2017 , ' Prognostic value of WHO grade in pancreatic neuro-endocrine tumors in Multiple Endocrine Neoplasia type 1 : Results from the DutchMEN1 Study Group ' , Pancreatology , vol. 17 , no. 5 , pp. 766-772 . https://doi.org/10.1016/j.pan.2017.07.196 |
| Schlagwörter: |
Multiple endocrine neoplasia type 1
/ Pancreatic neuroendocrine tumors
/ Liver metastases
/ WHO grade
/ Prognosis
/ KI67 PROLIFERATIVE INDEX
/ NATURAL-HISTORY
/ MEN1
/ CLASSIFICATION
/ EPIDEMIOLOGY
/ SURVIVAL
/ DEATH
/ GTE |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29027154 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://hdl.handle.net/11370/0b1b0f6b-c197-424f-a092-78629601b24e |
