BACKGROUND: Upfront primary tumor resection (PTR) has been associated with longer overall survival (OS) in patients with synchronous unresectable metastatic colorectal cancer (mCRC) in retrospective analyses. The aim of the CAIRO4 study was to investigate whether the addition of upfront PTR to systemic therapy resulted in a survival benefit in patients with synchronous mCRC without severe symptoms of their primary tumor. PATIENTS AND METHODS: This randomized phase III trial was conducted in 45 hospitals in The Netherlands and Denmark. Eligibility criteria included previously untreated mCRC, un... Mehr ...
| Verfasser: |
van der Kruijssen, D E W
Elias, S G
van de Ven, P M
van Rooijen, K L
Lam-Boer, J 't
Mol, L
Punt, C J A
Sommeijer, D W
Tanis, P J
Nielsen, J D
Yilmaz, M K
van Riel, J M G H
Wasowiz-Kemps, D K
Loosveld, O J L
van der Schelling, G P
de Groot, J W B
van Westreenen, H L
Jakobsen, H L
Fromm, A L
Hamberg, P
Verseveld, M
Jaensch, C
Liposits, G I
van Duijvendijk, P
Oulad Hadj, J
van der Hoeven, J A B
Trajkovic, M
de Wilt, J H W
Koopman, M |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2024 |
| Reihe/Periodikum: |
van der Kruijssen , D E W , Elias , S G , van de Ven , P M , van Rooijen , K L , Lam-Boer , J , Mol , L , Punt , C J A , Sommeijer , D W , Tanis , P J , Nielsen , J D , Yilmaz , M K , van Riel , J M G H , Wasowiz-Kemps , D K , Loosveld , O J L , van der Schelling , G P , de Groot , J W B , van Westreenen , H L , Jakobsen , H L , Fromm , A L , Hamberg , P , Verseveld , M , Jaensch , C , Liposits , G I , van Duijvendijk , P , Oulad Hadj , J , van der Hoeven , J A B , Trajkovic , M , de Wilt , J H W , Koopman , M & CAIRO4 Working Group 2024 , ' Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer : the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group ' , Annals of oncology : official journal of the European Society for Medical Oncology , vol. 35 , no. 9 , pp. 769-779 . https://doi.org/10.1016/j.annonc.2024.06.001 |
| Schlagwörter: |
Humans
/ Male
/ Colorectal Neoplasms/pathology
/ Female
/ Aged
/ Middle Aged
/ Antineoplastic Combined Chemotherapy Protocols/therapeutic use
/ Denmark/epidemiology
/ Netherlands/epidemiology
/ Bevacizumab/administration & dosage
/ Neoplasms
/ Multiple Primary/surgery
/ 80 and over
/ Adult
/ Neoplasm Metastasis
/ Survival Rate |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29026942 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://pure.au.dk/portal/en/publications/db3b7c01-8a62-4c09-b50f-8a213cb1505a |
