In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center

Abstract Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays a... Mehr ...

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Verfasser: Rümke, Lidewij W
Groenveld, Femke C
van Os, Yvonne M G
Praest, Patrique
Tanja, Anniek A N
de Jong, Dorien T C M
Symons, Jori
Schuurman, Rob
Reinders, Tessa
Hofstra, L Marije
Nierkens, Stefan
Thijsen, Steven F T
Heron, Michiel
Lebbink, Robert-Jan
Beekman, Jeffrey M
Nijhuis, Monique
Wensing, Annemarie M J
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Reihe/Periodikum: Open Forum Infectious Diseases ; volume 9, issue 1 ; ISSN 2328-8957
Verlag/Hrsg.: Oxford University Press (OUP)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29024262
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://dx.doi.org/10.1093/ofid/ofab553

Abstract Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.