The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation:a genetic case-control association study
Background Lifelong premature ejaculation (LPE) is a rare sexual condition believed to be caused by genetic neurobiological disorders.Aim In this study we sought to evaluate the genetic association between the rs6296 polymorphism of the 5-HT1b receptor and intravaginal ejaculation latency times (IELTs) in men with LPE compared with men in a control group.Methods This study was a prospective observational genetic case-control association study. The LPE definition of the International Society for Sexual Medicine (ISSM) 2013 was used. Patients were recruited in 2005-2009 while attending the depar... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2024 |
| Reihe/Periodikum: | van Raaij , J J & Janssen , P K C 2024 , ' The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation : a genetic case-control association study ' , Journal of sexual medicine , vol. 21 , no. 2 , 159 , pp. 122-128 . https://doi.org/10.1093/jsxmed/qdad159 |
| Schlagwörter: | lifelong premature ejaculation / single nucleotide polymorphism / rs6296 / genetic case-control association study / INTRAVAGINAL EJACULATION / LATENCY TIME / CAUCASIAN MEN / ANIMAL-MODELS / SEROTONIN / PREVALENCE / 5-HTTLPR / SOCIETY / DELAY / IELT |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-29021216 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/87ac0860-4c70-422a-a9cb-69cc2da52baf |
Background Lifelong premature ejaculation (LPE) is a rare sexual condition believed to be caused by genetic neurobiological disorders.Aim In this study we sought to evaluate the genetic association between the rs6296 polymorphism of the 5-HT1b receptor and intravaginal ejaculation latency times (IELTs) in men with LPE compared with men in a control group.Methods This study was a prospective observational genetic case-control association study. The LPE definition of the International Society for Sexual Medicine (ISSM) 2013 was used. Patients were recruited in 2005-2009 while attending the department of Neurosexology, HagaZiekenhuis, the Netherlands. We obtained IELTs with the stopwatch method. Polymerase chain reaction (PCR) was used for genotyping rs6296. A randomly selected group of European Caucasian men from the 1000GENOMES project was used as a control group.Outcomes Study outcomes included results of comparisons of analysis of variance (ANOVA) tests between genotypes and IELTs in study participants, genotypes of cases and controls determined with the chi-square test, and expressions of allelotype- and genotype-specific risks for LPE determined with odds ratios.Results In total, 67 men with LPE were included in this study. The geometric mean (SD) IELT was 32.0 (27.4) seconds and was non-normally distributed. Genotype frequencies consisted of 29 (43.3%) GG, 31 (46.3%) GC, and 7(10.4%) CC individuals in the LPE group. Log-transformed IELTs were not statistically significant (per ANOVA tests) in men with GG, GC, or CC genotypes (P = .54). Genotype frequencies consisted of 16 (6.6%) GG; 93 (38.8%) GC, and 131 (54.6%) CC individuals in the control group (n = 240). Significant differences were found when comparing allele (P = 1.02e-17) and genotype (P = 3.22e-16) frequencies in cases and controls using a chi-square test. A statistically significant increased risk for LPE was found for carriers of the G allele (OR 5.62; 95% CI 4.13-9.42). Statistically significant risks were also found for the CG genotype (OR 6.24; ...