Epigenetic changes may account for the doubled risk to develop schizophrenia in individuals exposed to famine in utero. We therefore investigated DNA methylation in a unique sample of patients and healthy individuals conceived during the great famine in China. Subsequently, we examined two case-control samples without famine exposure in whole blood and brain tissue. To shed light on the causality of the relation between famine exposure and DNA methylation, we exposed human fibroblasts to nutritional deprivation. In the famine-exposed schizophrenia patients, we found significant hypermethylatio... Mehr ...
| Verfasser: |
Boks, M. P.
Houtepen, L. C.
Xu, Z.
He, Y.
Ursini, G.
Maihofer, A. X.
Rajarajan, P.
Yu, Q.
Xu, H.
Wu, Y.
Wang, S.
Shi, J. P.
Pol, H. E. Hulshoff
Strengman, E.
Rutten, B. P. F.
Jaffe, A. E.
Kleinman, J. E.
Baker, D. G.
Hol, E. M.
Akbarian, S.
Nievergelt, C. M.
De Witte, L. D.
Vinkers, C. H.
Weinberger, D. R.
Yu, J.
Kahn, R. S. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Boks , M P , Houtepen , L C , Xu , Z , He , Y , Ursini , G , Maihofer , A X , Rajarajan , P , Yu , Q , Xu , H , Wu , Y , Wang , S , Shi , J P , Pol , H E H , Strengman , E , Rutten , B P F , Jaffe , A E , Kleinman , J E , Baker , D G , Hol , E M , Akbarian , S , Nievergelt , C M , De Witte , L D , Vinkers , C H , Weinberger , D R , Yu , J & Kahn , R S 2018 , ' Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia ' , npj Schizophrenia , vol. 4 , no. 1 , 16 . https://doi.org/10.1038/s41537-018-0058-4 |
| Schlagwörter: |
POSTMORTEM HUMAN BRAIN
/ DNA METHYLATION
/ ADULT SCHIZOPHRENIA
/ PRENATAL EXPOSURE
/ DUTCH |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29021199 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/81b9c31a-1761-44cb-9dff-49f98fce775c |
