The Dutch Parelsnoer Institute - Neurodegenerative diseases; methods, design and baseline results

Background: The Parelsnoer Institute is a collaboration between 8 Dutch University Medical Centers in which clinical data and biomaterials from patients suffering from chronic diseases (so called "Pearls") are collected according to harmonized protocols. The Pearl Neurodegenerative Diseases focuses on the role of biomarkers in the early diagnosis, differential diagnosis and in monitoring the course of neurodegenerative diseases, in particular Alzheimer's disease. The objective of this paper is to describe the design and methods of the Pearl Neurodegenerative Diseases, as well as baseline descr... Mehr ...

Verfasser: Aalten, Pauline
Ramakers, Inez H. G. B.
Biessels, Geert Jan
de Deyn, Peter Paul
Koek, Huiberdina L.
OldeRikkert, Marcel G. M.
Oleksik, Ania M.
Richard, Edo
Smits, Lieke L.
van Swieten, John C.
Teune, Laura K.
van der Lugt, Aad
Barkhof, Frederik
Teunissen, Charlotte E.
Rozendaal, Nico
Verhey, Frans R. J.
van der Flier, Wiesje M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2014
Reihe/Periodikum: Aalten , P , Ramakers , I H G B , Biessels , G J , de Deyn , P P , Koek , H L , OldeRikkert , M G M , Oleksik , A M , Richard , E , Smits , L L , van Swieten , J C , Teune , L K , van der Lugt , A , Barkhof , F , Teunissen , C E , Rozendaal , N , Verhey , F R J & van der Flier , W M 2014 , ' The Dutch Parelsnoer Institute - Neurodegenerative diseases; methods, design and baseline results ' , BMC Neurology , vol. 14 , 254 . https://doi.org/10.1186/s12883-014-0254-4
Schlagwörter: Dementia / Alzheimer's disease / Design / Biobank / Research infrastructure
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29020661
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://cris.maastrichtuniversity.nl/en/publications/293d2388-616e-4969-a25c-c942945223b7

Background: The Parelsnoer Institute is a collaboration between 8 Dutch University Medical Centers in which clinical data and biomaterials from patients suffering from chronic diseases (so called "Pearls") are collected according to harmonized protocols. The Pearl Neurodegenerative Diseases focuses on the role of biomarkers in the early diagnosis, differential diagnosis and in monitoring the course of neurodegenerative diseases, in particular Alzheimer's disease. The objective of this paper is to describe the design and methods of the Pearl Neurodegenerative Diseases, as well as baseline descriptive variables, including their biomarker profile. Methods: The Pearl Neurodegenerative Diseases is a 3-year follow-up study of patients referred to a memory clinic with cognitive complaints. At baseline, all patients are subjected to a standardized examination, including clinical data and biobank materials, e.g. blood samples, MRI and cerebrospinal fluid. At present, in total more than 1000 patients have been included, of which cerebrospinal fluid and DNA samples are available of 211 and 661 patients, respectively. First descriptives of a subsample of the data (n = 665) shows that patients are diagnosed with dementia (45%), mild cognitive impairment (31%), and subjective memory complaints (24%). Discussion: The Pearl Neurodegenerative Diseases is an ongoing large network collecting clinical data and biomaterials of more than 1000 patients with cognitive impairments. The project has started with data analyses of the baseline characteristics and biomarkers, which will be the starting point of future specific research questions that can be answered by this unique dataset.