Quality of life among patients with 4 to 10 brain metastases after treatment with whole-brain radiotherapy vs. stereotactic radiotherapy: a phase III, randomized, Dutch multicenter trial

Background: Stereotactic radiotherapy (SRT) is an attractive treatment option for patients with brain metastases (BM), sparing healthy brain tissue and likely controlling local tumors. Most previous studies have focused on radiological response or survival. Our randomized trial (NCT02353000) investigated whether quality of life (QoL) is better preserved using SRT than whole-brain radiotherapy (WBRT) for patients with multiple BM. Recently, we published our trial's primary endpoints. The current report discusses the study's secondary endpoints.Methods: Patients with 4 to 10 BM were randomly ass... Mehr ...

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Verfasser: Hartgerink, D.
Bruynzeel, A.
Eekers, D.
Swinnen, A.
Hurkmans, C.
Wiggenraad, R.
Swaak-Kragten, A.
Dieleman, E.
Van der Toorn, P.P.
van Veelen, L.
Verhoeff, J.J.C.
Lagerwaard, F.
de Ruysscher, D.
Lambin, P.
Zindler, J.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Hartgerink , D , Bruynzeel , A , Eekers , D , Swinnen , A , Hurkmans , C , Wiggenraad , R , Swaak-Kragten , A , Dieleman , E , Van der Toorn , P P , van Veelen , L , Verhoeff , J J C , Lagerwaard , F , de Ruysscher , D , Lambin , P & Zindler , J 2022 , ' Quality of life among patients with 4 to 10 brain metastases after treatment with whole-brain radiotherapy vs. stereotactic radiotherapy: a phase III, randomized, Dutch multicenter trial ' , Annals of palliative medicine , vol. 11 , no. 4 , pp. 1197-1209 . https://doi.org/10.21037/apm-21-1545
Schlagwörter: Brain metastases (BM) / stereotactic radiotherapy (SRT) / randomized controlled trial / palliative treatment / quality of life (QoL) / SURGICAL RESECTION / EORTC QLQ-BN20 / RADIOSURGERY / CANCER
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29020518
Datenquelle: BASE; Originalkatalog
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Link(s) : https://cris.maastrichtuniversity.nl/en/publications/062039ea-698a-48c8-8321-eb29dde358ef