Inspection of functional elements near the GC CNV.
Functional elements were inspected in GC eQTL region using ChIP-seq (H3K27ac and H3K4me3) and ATAC-seq data. The GC CNV genotype of the ATAC-seq sample was Mul/Mul (inferred based on CNV tagging SNP genotypes and read-depth increase in WGS data). The GC CNV genotype of the ChIP-seq sample was unknown ( S9 Table ).(A) The GC eQTL region was zoomed in. In this region, GC is the only annotated gene. The GC CNV is marked with the translucent blue, and CM resistance candidate SNPs reported by other studies [ 13 , 14 ] are marked with translucent yellow. Other significant eQTL lead SNPs in this regi... Mehr ...
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Dokumenttyp: | Image |
Erscheinungsdatum: | 2021 |
Schlagwörter: | Genetics / Neuroscience / Evolutionary Biology / Cancer / Infectious Diseases / Plant Biology / Virology / Environmental Sciences not elsewhere classified / Biological Sciences not elsewhere classified / dairy cattle Clinical mastitis / multiplicated allele / SNP / vitamin D pathway / vitamin D binding protein / group-specific component gene / Dutch dairy cattle population / CM resistance QTL / GC gene enhancer / CNV / dairy cattle breeds / variant / 12 kb multi-allelic copy number var. / expression QTL mapping |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-29019097 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.1371/journal.pgen.1009331.g006 |