Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques
Alzheimer´s disease is a severe neurodegenerative disorder of the brain, pathologically characterized by extracellular beta-amyloid plaques, intraneuronal Tau inclusions, inflammation, reactive glial cells, vascular pathology and neuronal cell death. The degradation and clearance of beta-amyloid plaques is an interesting therapeutic approach, and the proteases neprilysin (NEP), insulysin and matrix metalloproteinases (MMP) are of particular interest. The aim of this project was to establish and characterize a simple in vitro model to study the degrading effects of these proteases. Organoytpic... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2015 |
Reihe/Periodikum: | Frontiers in Aging Neuroscience, Vol 7 (2015) |
Verlag/Hrsg.: |
Frontiers Media S.A.
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Schlagwörter: | Alzheimer / Clearance / in vitro model / beta-amyloid plaques / organotypic brain slices / vibrosections / Neurosciences. Biological psychiatry. Neuropsychiatry / RC321-571 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28987169 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.3389/fnagi.2015.00047 |