Cost-Effectiveness and Projected Survival of Self-Expanding Transcatheter Versus Surgical Aortic Valve Replacement for High Risk Patients in a European Setting: A Dutch Analysis Based on the CoreValve High Risk Trial ...

Background: Clinical and economic outcomes of self-expanding bioprosthetic transcatheter aortic valve implantation (TAVI) in high-risk surgical candidates are unknown in the European setting. The objective of this study was to project life expectancy and to estimate the cost-effectiveness of TAVI in a European setting. Methods: Cost-utility analysis via probabilistic Markov modeling was performed. A simulated cohort of 83-year-old men and women (53 and 47%, respectively) with severe aortic stenosis at high but not extreme surgical risk were observed in the CoreValve High Risk Trial. Costs were... Mehr ...