Cost-effectiveness and Projected Survival of Self-expanding Transcatheter versus Surgical Aortic Valve Replacement for High Risk Patients in a European Setting. A Dutch Analysis Based on the CoreValve High-Risk Trial ...

Background : Clinical and economic outcomes of self-expanding bioprosthesis transcatheter aortic valve implantation (TAVI) in high-risk surgical candidates are unknown in the European setting. The objective is to project life expectancy and estimate the cost-effectiveness of TAVI in a European setting. Methods : Cost-utility analysis via probabilistic Markov modeling was performed. A simulated cohort of 83-year old men and women (53 and 47%, respectively) with severe aortic stenosis at high but not extreme surgical risk were observed in the CoreValve High Risk Trial. Costs were based on resour... Mehr ...